The Seasonal School on “Heterogeneous Cyber-Physical Systems of Systems (HEPSoS) 2019” was held in Thessaloniki on 29 November - 1 December 2019 and was organized by Assoc. Prof. Yannis Papaefstathiou and Prof. Alkis Hatzopoulos, from the Computer Architecture Lab and the Electronics Lab of the Department of Electrical and Computer Eng., respectively. The presentations covered topics like Design of Embedded Systems software, Design of FPGA systems, Security in CPSoS, sensors, signal conditioning circuits, energy harvesting, as well as laboratory work on FPGA Design using Vivado software. The lectures were offered by experts in the specific fields from Academia and Industry from Greece and abroad. A special session about IEEE CAS Society and IEEE Greece CAS/SSC joint Chapter activities was also organized.